Comparing the impact of cumulative insulin resistance surrogates exposure on stroke: optimizing prevention strategies

Table 1 Calculation method of IR surrogates and CumIR surrogates

	Calculation method	Reference
TyG index	TyG index = ln [TG (mg/dL) × FPG (mg/dL)/2]	[12]
TG/HDL-C ratio	TG/HDL-C ratio = TG (mg/dL) / HDL-C (mg/dL)	[13]
MetS-IR	MetS-IR = Ln [(2 × FPG (mg/dL)) + fasting TG (mg/dL)] × BMI (kg/m²) / (Ln [HDL-C (mg/dL)]).	[14]
eGDR	eGDR = 21.158 − (0.09 × WC) − (3.407 × hypertension) − (0.551 × HbA1c) [WC (cm), hypertension (yes = 1/no = 0), and HbA1c (%)].	[15]
CumTyG index	CumTyG index = (TyG index2012 + TyGindex2015)/2* time (2012 − 2015)	[20]
CumTG/HDL-C ratio	CumTG/HDL-C ratio = (TG/HDL-C ratio2012 + TG/HDL-C ratio2015)/2* time (2012 − 2015)
CumMetS-IR	CumMetS-IR = (MetS-IR2012 + MetS-IR2015)/2* time (2012 − 2015)	[21]
CumeGDR	CumeGDR = (eGDR2012 + eGDR2015)/2* time (2012 − 2015)	[22]

Abbreviations: IR: insulin resistance; CumIR: cumulative insulin resistance; TyG: triglyceride-glucose; TG/HDL-C: triglyceride to high-density lipoprotein cholesterol; MetS-IR: metabolic score for insulin resistance; eGDR: estimated glucose disposal rate; CumTyG: cumulative triglyceride-glucose; CumMetS-IR: cumulative metabolic score for insulin resistance; CumTG/HDL-C: cumulative triglyceride to high-density lipoprotein cholesterol; CumeGDR: cumulative estimated glucose disposal rate

ISSN: 1476-511X