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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Arachidonic acid is involved in high-salt diet-induced coronary remodeling through stimulation of the IRE1α/XBP1s/RUNX2/OPN signaling cascade

Fig. 1

A high-salt diet induces myocardial ischemia accompanied by elevated arachidonic acid levels. (A) Construction of the animal model. (B) Results of the rat electrocardiogram (n = 4). (C) TTC staining results of rat hearts (n = 4). (D) Experimental design, including measurement of serum AA levels and COX-2 protein expression in coronary arteries. (E) Serum AA levels in the rats (n = 8). (F) Western blot analysis of COX-2 protein expression in coronary arteries and (G) analysis of band density (n = 3). (H) Immunofluorescence detection of COX-2 expression in coronary arteries and (I) analysis of fluorescence intensity (n = 4). The data are presented as the means ± SEMs, *P < 0.05, **P < 0.01, compared with the data of the control group. Abbreviations: TTC, triphenyltetrazolium chloride; AA, arachidonic acid; COX-2, cyclooxygenase-2

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Lipids in Health and Disease

ISSN: 1476-511X